Inventor

MCLAREN, Earl; MCLAREN, Derek

Número de Publicación

WO2021207822A1

Solicitante 

MCPHARMA BIOTECH INC.

Abstract

Protein fermentation by the gut microbiome generates a number of metabolites, including the uremic toxins indoxyl sulfate (IS) and p-cresol sulfate (p-CS). RS consumption significantly altered the microbiome while improving several measures of protein fermentation in the gut. The use of RS by those needing to reduce the effects of protein fermentation, for example patients with chronic kidney disease, can be guided by simultaneously measuring changes in select genera in the microbiome

Resumen

Se describe un método basado en análisis ómicos para determinar la eficacia de un tratamiento de modulación del microbioma para metabolitos nocivos relacionados con la enfermedad renal en individuos con riesgo de desarrollar la enfermedad o que la está padeciendo.