Inventor

HORVATH STEFAN [US]; LU AKE TZU-HUI [US] +

Publication number

US2022119885 (A1)

Applicant

UNIV CALIFORNIA [US] +

Abstract

The disclosure provides seven DNAm-based estimators of plasma protein levels including those of plasminogen activation inhibitor 1 (PAI-1) and growth differentiation factor 15 (GDF15). The predictor of lifespan, DNAm GrimAge (in units of years), is a composite biomarker based on the seven DNAm surrogate markers and a DNAm-based estimator of smoking pack-years. These novel DNAm based biomarkers show the expected relationship…