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Glycan polymers and related methods thereof

Inventor

 

Molly Krisann Gibson (Medford, MA), Christopher Matthew Liu (Somerville, MA), Geoffrey A. von Maltzahn (Somerville, MA), Han Yuan (Arlington, MA) 

 

Publication Number

 

20190290675 

 

Applicant

 

Kaleido Biosciences Inc. 

 

Abstract

 

The microbiota of humans is complex, and varies by individual depending on genetics, age, sex, stress, nutrition and diet. The microbiota performs many activities and may influence the physiology of the host. Modulating the gut microbiota can alter community function and interaction with the host. A limited number of probiotic bacteria are known in the art, and some association with health benefits are documented when the probiotic bacteria are taken by humans. Some foods are considered ‘prebiotic’ foods that contain substances that may promote the growth of certain bacteria that are thought to be beneficial to the human host. The results of clinical tests with these substances are conflicted with respect to their efficacy, and their influence on human health is generally described as being modest. Thus, there is a need for novel inputs that can modulate the microbiota and improve human health. 

The invention is directed to a method of treating a subject having a disease or disorder associated with an unwanted level of a metabolite and the selection of a glycan polymer preparation on the basis that it modulates the production or level of the metabolite. 

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