25
Mar
Human Pluripotent Stem Cell-Based Models For Predictive Developmental Neural Toxicity
Comments
Inventor
James A. Thomson (Madison, WI), William L. Murphy (Waunakee, WI), Charles D. Page (Sun Prairie, WI), Michael P. Schwartz (Madison, WI), Zhonggang Hou (Madison, WI)
Publication Number
20160186146
Applicant
Wisconsin Alumni Research Foundation (US)
Abstract
The present invention relates to three-dimensional (3D) tissue constructs and methods of using such 3D tissue constructs to screen for neurotoxic agents. In particular, provided herein are methods of producing and using complex, highly uniform human tissue models comprising physiologically relevant human cells, where the tissue models have the degree of sample uniformity and reproducibility required for use in quantitative high-throughput screening applications.