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Impact of Extreme Obesity and Diet-Induced Weight Loss on the Fecal Metabolome and Gut Microbiota

Authors

 

Alicja M. Nogacka, Clara G. de los Reyes-Gavilán, Ceferino Martínez-Faedo,
Patricia Ruas-Madiedo, Adolfo Suarez, Leonardo Mancabelli, Marco Ventura
Alejandro Cifuentes, Carlos León, Miguel Gueimonde, and Nuria Salazar.

 

Abstract

 

Microbiota profiles are distinct between normal-weight and obese participants and are accompanied by fecal signatures in the metabolism of biliary compounds and catecholamines. Moderate diet-induced weight loss promotes shifts in the gut microbiota, and the primary fecal metabolomics features are associated with diet and the gut–liver and gut–brain axes.

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