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Multi-omics reveals diet-induced metabolic disorders and liver inflammation via microbiota-gut-liver axis

Autores

 

Bing Wang, Boyan Zhang, Lin Zhou, Shuanghong Li, Zhen Li, Hailing Luo

 

Abstract

 

The gut microbiota medicated gut-liver axis is vital for liver function and health. We aimed to explore the underlying molecular mechanism of diet-induced metabolic liver disorders via microbiota-gut-liver axis using multi-omics. Several omics were conducted on liver tissue and biofluids (gastrointestinal contents and blood) to elucidate the microbial mechanism related to metabolic disorders and liver injury. The hepatic inflammation occurred based on histomorphology after feeding a long-term grain-based high-energy diet, and the serum biochemical parameters and proinflammatory cytokines were significantly activated. The high-energy diet promoted hepatic inflammatory response and cytokine/chemokine-mediated signaling pathways located in the core of the functional genomic network. Integrated multi-omics analyses showed interactions among the rumen and jejunum microbiota, circulating metabolites, and liver gene expression, suggesting a systemic immune response and liver disorder that signals through the microbiota-gut-liver axis.

 

Resumen del artículo

 

El trabajo, realizado en rumiantes, explora el mecanismo molecular subyacente de los trastornos hepáticos metabólicos inducidos por la dieta, a través del eje microbiota-intestino-hígado utilizando multiómicas. Se realizadon análisis metataxonómicos, metaproteómicos, transcriptómicos y metabolómicos en tejido hepático, contenido gastrointestinal y sangre para dilucidar el mecanismo microbiano relacionado con los trastornos metabólicos y la lesión hepática. Los análisis multiómicos integrados mostraron interacciones entre la microbiota del rumen y el yeyuno, los metabolitos circulantes y la expresión génica del hígado, lo que sugiere una respuesta inmunitaria sistémica y un trastorno hepático que envía señales a través del eje microbiota-intestino-hígado.

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